DRD4 encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in DRD4 have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. DRD4 contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. 蛋白别名为:DRD4; D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor;基因ID为:1815;蛋白质ID:P21917
应用类型
WB,IF,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IF: 1:200-1:1000, ELISA: 1:40000. Not yet tested in other applications.
免疫原
合成多肽:the C-terminal region of human D4DR. at AA rangle: 330-410