CFL2 encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. Cofilin 2 is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in CFL2 cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. 蛋白别名为:CFL1; CFL; Cofilin-1; 18 kDa phosphoprotein; p18; Cofilin; non-muscle isoform; CFL2; Cofilin-2; Cofilin, muscle isoform;基因ID为:1073/1072;蛋白质ID:P23528/Q9Y281
应用类型
WB,IF,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IF: 1:200-1:1000, ELISA: 1:40000. Not yet tested in other applications.
免疫原
合成多肽:the Internal region of human Cofilin. at AA rangle: 30-110