The protein encoded by CTSH is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein(cathepsin H), which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of CTSH has been correlated with malignant progression of prostate tumors. Alternate splicing of CTSH results in multiple transcript variants encoding different isoforms. 蛋白别名为:CTSH; CPSB; Pro-cathepsin H;基因ID为:1512;蛋白质ID:P09668
应用类型
WB,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽:the Internal region of human Cathepsin H. at AA rangle: 70-150