Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate，the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate，regulates levels of mercaptopyruvate，an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
应用类型
WB
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GOT1
