The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling，through phosphorylations and protein-protein interactions. Modulates signaling in ERK，SRC and NF-kappa-B pathways. In activated T-cells，influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds，together with KLF4，the PE21 promoter element of TP53 and represses TP53 activity.
应用类型
Western Blot
免疫原
Purified His-tagged MUC1 protein (N-terminal fragment)
