This gene is a member of the cullin family. The encoded
protein forms a complex that functions as an E3 ubiquitin ligase
and catalyzes the polyubiquitination of specific protein substrates
in the cell. The protein interacts with a ring finger protein, and
is required for the proteolysis of several regulators of DNA
replication including chromatin licensing and DNA replication
factor 1 and cyclin E. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].
