WD40 repeat proteins are key components of many essential
biologic functions. They regulate the assembly of multiprotein
complexes by presenting a beta-propeller platform for simultaneous
and reversible protein-protein interactions. Members of the WIPI
subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed
propeller structure and contain a conserved motif for interaction
with phospholipids (Proikas-Cezanne et al., 2004 [PubMed
15602573]).
