The anaphylatoxins C3a (see MIM 120700), C4a (see MIM
120810), and C5a are cationic fragments generated during the
complement cascade that participate in host defense. In the case of
inappropriate complement activation, anaphylatoxins may be involved
in autoimmunity and sepsis. C5L2 is coexpressed with the C5a
receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils
and may modulate C5AR activity (Gerard et al., 2005 [PubMed
16204243]).
