This gene encodes a cyclin-dependent kinase inhibitor,
which shares a limited similarity with CDK inhibitor CDKN1A/p21.
The encoded protein binds to and prevents the activation of cyclin
E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle
progression at G1. The degradation of this protein, which is
triggered by its CDK dependent phosphorylation and subsequent
ubiquitination by SCF complexes, is required for the cellular
transition from quiescence to the proliferative state. [provided by
RefSeq].
