The protein encoded by this gene is a transmembrane
glycoprotein belonging to the immunoglobulin superfamily. The
external domain mediates cell attachment to the extracellular
matrix molecule vitronectin, while its intracellular domain
interacts with the dynein light chain Tctex-1/DYNLT1. The gene is
specific to the primate lineage, and serves as a cellular receptor
for poliovirus in the first step of poliovirus replication.
Multiple transcript variants encoding different isoforms have been
found for this gene.
