The protein encoded by this gene is a member of the PP2C
family of Ser/Thr protein phosphatases. PP2C family members are
known to be negative regulators of cell stress response pathways.
This phosphatase can interact with Rho guanine nucleotide exchange
factors (PIX), and thus block the effects of p21-activated kinase 1
(PAK), a protein kinase mediating biological effects downstream of
Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma
(CAMK2G/CAMK-II) is found to be one of the substrates of this
phosphatase. The overexpression of this phosphatase or CAMK2G has
been shown to mediate caspase-dependent apoptosis. An alternatively
spliced transcript variant has been identified, but its full-length
nature has not been determined.
