Alpha-1-adrenergic receptors (alpha-1-ARs) are members of
the G protein-coupled receptor superfamily. They activate mitogenic
responses and regulate growth and proliferation of many cells.
There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of
which signal through the Gq/11 family of G-proteins and different
subtypes show different patterns of activation. This gene encodes
alpha-1B-adrenergic receptor, which induces neoplastic
transformation when transfected into NIH 3T3 fibroblasts and other
cell lines. Thus, this normal cellular gene is identified as a
protooncogene. This gene comprises 2 exons and a single large
intron of at least 20 kb that interrupts the coding region.
