NEPH1 is a member of the nephrin-like protein family,
which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The
cytoplasmic domains of these proteins interact with the C terminus
of podocin (NPHS2; MIM 604766), and the genes are expressed in
kidney podocytes, cells involved in ensuring size- and
charge-selective ultrafiltration (Sellin et al., 2003 [PubMed
12424224]).
