Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr
protein kinase involved in cell growth and transformation. This
gene encodes a protein similar to the E2 ubiquitin conjugating
enzyme UBC3/CDC34. Studies suggest that CK2-dependent
phosphorylation of this ubiquitin-conjugating enzyme functions by
regulating beta-TrCP substrate recognition and induces its
interaction with beta-TrCP, enhancing beta-catenin degradation.
