Histone acetylation and deacetylation, catalyzed by
multisubunit complexes, play a key role in the regulation of
eukaryotic gene expression. The protein encoded by this gene
belongs to the histone deacetylase/acuc/apha family and is a
component of the histone deacetylase complex. It also interacts
with retinoblastoma tumor-suppressor protein and this complex is a
key element in the control of cell proliferation and
differentiation. Together with metastasis-associated protein-2, it
deacetylates p53 and modulates its effect on cell growth and
apoptosis.
