DuSP10 (Dual specificity protein phosphatase 10) belongs to the protein-tyrosine phosphatase family. Dual specificity protein phosphatases (DuSPs) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. DuSP10 has been shown to interact with MAPK14 and MAPK8. When expressed in mammalian cells, DuSP10 blocks the enzymatic activation of MAP kinases with the selectivity p38 approximately JNK/SAPK >> ERK. Recombinant human DuSP10 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
序列
重组人DUSP10蛋白产品，又称Dual specificity protein phosphatase 10, MKP5.其对应NCBI基因号为11221，对应Accession号为Q9Y6W6 .
来源宿主
提供的【DUSP10】重组人DUSP10产品的来源为大肠杆菌重组表达.
溶解建议
重组人DUSP10产品为液体即用型，其溶液组成为：0.25 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 50% glycerol, 0.2 M NaCl and 2 mM DTT
