- 中文名称
【SGK1】SGK1蛋白,有活性的(5 ug)
- 英文名字
- SGK1, Active
- 供应商
- Biovision
- 产品货号
- 7748-5
- 产品报价
- ¥已停产

- 产品说明书
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- 购买方式
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- 产品新闻

- 背景资料
- SGK1 is a member of the serum- and glucocorticoid-induced protein kinase that is activated in vitro by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and in vivo in response to signals that activate phosphatidylinositol (PI) 3-kinase (1). SGK1, mRNA is expressed in all tissues and the levels of SGK1 mRNA is increased by stimulation with serum or dexamethasone.
SGK1 promotes cell survival by phosphorylating and inactivating FKHRL1. SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK1 displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK1 and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. Like PKB, SGK1 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs. SGK1 gene has recently been identified as an important aldosterone-induced protein kinase that mediates trafficking of the renal epithelial Na(+) channel (ENaC) to the cell membrane. Thus, SGK1 is an appealing candidate for blood pressure regulation and possibly essential hypertension (3).
- 序列
- SGK1蛋白,有活性的蛋白产品,又称SGK, serum/glucocorticoid regulated kinase 1.其对应NCBI基因号为8767,NCBI基因别称为RIPK2源,对应Accession号为O43353.该蛋白产品又称SGK-1, SGK 1, Active SGK1, SGK1, SGK, human SGK1, active kinase, active kinases, recombinant SGK1, recombinant SGK, kinase activity assay, protein kinase等.
- 来源宿主
- 提供的【SGK1】SGK1蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.
- 溶解建议
- 提供的SGK1蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.
- 保存建议
- 在您收到艾美捷发出的【SGK1】SGK1蛋白,有活性的产品后,建议将其置于-80°C保存.
- 其他
- BioVision的公司总部在美丽的旧金山湾地区,它是全球生命科学公司的Leader,BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品,以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理,艾美捷与BioVision一起为研究者们提供优质、新的细胞生物学研究工具而不断扩大产品及服务质量.

- 注意
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该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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