中文名称

【Lck】Lck蛋白，有活性的（5微克）

英文名字

Lck, Active

供应商

Biovision

产品货号

7733-5

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Lck (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene. Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show overexpression of Lck, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers. Colon cancers and T-cell leukemias frequently show defective regulation of Lck expression and activity.Inappropriate T cell activation and proliferation have been identified as an early event in auto-immune disease. Lck plays a prominent role in T-cell development, activation, proliferation and survival. Lck is coupled to both the CD4 and CD8 antigens (which serve as receptors for nonpolymorphic regions of products of the major histocompatibility complex and have been implicated in the regulation of T-cell growth) in T-cells and phosphorylates CD3. Lck phosphorylates many cellular protein substrates as a result of T-cell receptor signaling cascade. This includes phosphorylation of proteins such as Ras GTPase-activating protein (RasGAP) and two RasGAP-associated proteins, p56(dok) and p62(dok).

序列

Lck蛋白,有活性的蛋白产品，又称Lck (or leukocyte-specific protein tyrosine kinase), Leukocyte C-terminal Src kinase, Short name=LSK, Lymphocyte cell-specific protein-tyrosine kinase, Protein YT16, Proto-oncogene Lck, T cell-specific protein-tyrosine kinase, p56-LCK .其对应NCBI基因号为660，NCBI基因别称为BMX源，对应Accession号为P51813.该蛋白产品又称Active Lck, Lck, human Lck, active kinase, active kinases, recombinant Lck, recombinant Lck, kinase activity assay, protein kinase等.

来源宿主

提供的【Lck】Lck蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达.

溶解建议

提供的Lck蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中.

保存建议

在您收到艾美捷发出的【Lck】Lck蛋白,有活性的产品后，建议将其置于-80°C保存.

其他

BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的Leader，BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供优质、新的细胞生物学研究工具而不断扩大产品及服务质量.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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