Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The function of FNDC4 is unknown. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes.
序列
重组人/小鼠FNDC4蛋白产品，又称Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1.其对应NCBI基因号为64838，对应Accession号为Q9H6D8.
来源宿主
提供的【FNDC4】重组人/小鼠FNDC4产品的来源为大肠杆菌重组表达.
溶解建议
重组人/小鼠FNDC4产品请按照说明书建议进行溶解操作：Reconstitute with 100 ul sterile distilled water.
