Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
序列
重组小鼠Notch-1蛋白蛋白产品，又称Neurogenic Locus Notch Homolog Protein 1; Notch A; mT14; p300.其对应NCBI基因号为18128，对应Accession号为Q01705.
来源宿主
提供的【Notch 1】重组小鼠Notch-1蛋白产品的来源为中国仓鼠卵巢CHO细胞重组表达.
溶解建议
重组小鼠Notch-1蛋白产品请按照说明书建议进行溶解操作：Reconstitute with sterile water to 1 mg/ml.
