中文名称

【PD-1 / PDCD1】重组小鼠PD-1 / PDCD1蛋白（10 ug）

英文名字

Human CellExp PD-1 /PDCD1, mouse recombinant

供应商

Biovision

产品货号

7499-10

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. This protein is suitable for use in protein studies such as protein structure analysis and protein-protein interactions. It can also be used as an immunogen, as a protein standard, or in cell biology research applications.

序列

重组小鼠PD-1 /PDCD1蛋白又称PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l.其对应NCBI基因号为18566，对应Accession号为Q02242.

来源宿主

提供的【PD-1/PDCD1】重组小鼠PD-1 /PDCD1蛋白产品来源为人胚肾HEK 293细胞中重组表达.

溶解建议

重组小鼠PD-1 /PDCD1蛋白产品为冻干形式，打开产品储存管之前请离心.将其重新溶解于无菌的PBS缓冲液（pH 7.4）中到终浓度为50 ug/ml，避免涡旋溶解.

保存建议

在您收到艾美捷发出的【PD-1/PDCD1】重组小鼠PD-1 /PDCD1蛋白产品后，建议将其置于-20°C保存，产品有效期为收到产品后12个月.

其他

BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的Leader，BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供优质、新的细胞生物学研究工具而不断扩大产品及服务质量.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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