TREM2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
序列
重组人TREM2蛋白产品，又称Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c.其对应NCBI基因号为54209，对应Accession号为Q9NZC2.
来源宿主
提供的【TREM2】重组人TREM2产品的来源为大肠杆菌重组表达.
溶解建议
重组人TREM2产品为液体即用型，其溶液组成为：0.25 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 10% glycerol.
