BCRP，also called ABCG2，is encoded by the ABCG2 gene. BCRP is a well-characterized ABC-transporter (which limits uptake or mediates efflux of a wide variety of drugs，carcinogens，dietary toxins across cellular membranes). It is an ATP-dependent pump with broad substrate specificity. Significant expression has been observed in the placenta and it has been shown to have a role in protecting the fetus from xenobiotics in the maternal circulation. It plays protective roles in blocking absorption at the apical membrane of the intestine，and at the blood-testis barrier，the blood–brain barrier and the membranes of hematopoietic progenitor and other stem cells. At the apical membranes of the liver and kidney，it enhances excretion of xenobiotics. In the lactating mammary gland，it has a role on excreting vitamins such as riboflavin and biotin into milk.
应用类型
Western Blot
免疫原
Synthetic peptide corresponding to amino acids around position 160 of human ABCG2
