P-gp，also called MDR1 or ABCB1，is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of xenobiotics across extra- and intracellular membranes). It is an ATP-dependent drug efflux pump with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein functions in the kidneys，liver，blood–brain barrier and the intestinal epithelium.
应用类型
IHC-P, IHC-F
免疫原
Synthetic peptide corresponding to amino acids around position 630 of human P-glycoprotein
