TRIB1 antibody，also called gprotein coupled receptor induced，skip1，gig2，c8fwATP，functions in protein binding，protein kinase inhibitor activity，and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3，and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1，indicating that the TRIB-MAPKK interaction stabilized TRIB1
应用类型
Western blot
免疫原
This TRIB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human TRIB1
