T-cell surface glycoprotein CD3 delta chain，also known as CD3D，is a single-pass type I membrane protein. CD3D，together with CD3-gamma,CD3-epsilon and CD3-zeta，and the T-cell receptor alpha/beta and gamma/delta heterodimers，forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function，and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine based activation motifs (ITAMs). Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK cell-positive (T-/B+/NK+SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity，leukopenia，and low or absent antibody levels.
应用类型
WB: 1:500 - 1:1000, IF/IC: 1:100 – 1:500
免疫原
This CD3d antibody is generated from KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD3d. The exact sequence is proprietary.
