CD1E encodes a member of the CD1 family of transmembrane glycoproteins，which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments，endosomes，and lysosomes，and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members.
应用类型
WB: 1:500 - 1:1000, IF/IC: 1:100 – 1:500
免疫原
This CD1e antibody is generated from KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD1e. The exact sequence is proprietary.
