TAF1 is the largest component and core scaffold of the TFIID basal transcription factor complex which also includes TBP. The protein is able to auto phosphorylate or trans phosphorylate other transcription factors such as TP53 on ‘Thr-55’，leading to MDM2-mediated degradation of TP53，and GTF2A1 and GTF2F1 on Ser residues. TAF1 possesses DNA-binding activity and is essential for progression of the G1 phase of the cell cycle.
应用类型
Western Blot: 1:1000.
免疫原
Polyclonal antibody raised in rabbit against human TAF1 （TATA box binding protein （TBP）-associated factor； Transcription initiation factor TFIID subunit 1）， using the recombinant double bromodomain module of the protein.
