CBX2 is a component of a Polycomb group （PcG） multiprotein PRC1-like complex，a complex class required to maintain the transcriptionally repressive state of many genes，including Hox genes，throughout development. The PcG PRC1 complex acts via chromatin remodelling and modification of histones； it mediates monoubiquitination of lysine 119 on histone H2A，rendering chromatin heritably changed in its expressibility. CBX2 also is involved in sexual development，acting as an activator of NR5A1 expression.
应用类型
ELISA: 1:300.
免疫原
Polyclonal antibody raised in rabbit against mouse CBX2 （chromobox homolog 2） using two KLH-conjugated synthetic peptides containing a sequence from the central region of the protein.
