This antibody specifically recognizes the AML1 （RUNX1） - ETO （RUNX1T1） fusion protein that arises due to a translocation between chromosome 8 and 22 （t（8；21）（q22；q22））. This translocation is one of the most frequent karyotypic abnormalities observed in acute myeloid leukemia. It produces a chimerical gene made up of the 5’-region of AML1and the 3’-region of ETO. The chimerical protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
应用类型
ChIP: 4 ug/ChIP， WB: 1:1000， ELISA: 1:500
免疫原
Polyclonal antibody raised in rabbit against the Runx1-ETO fusion protein using a KLH-conjugated synthetic peptide.
