Angptl1 （angiopoietin-like 1），also known as angioarrestin，ARP1，ANGPT3 or previously known as angiopoietin 3 （ANG3），is a member of the angiopoietin-like family. It is highly expressed in adult tissues，particularly adrenal gland，thyroid，placenta and small intestine. Angptl1 exists as a disulfide-linked dimer and shares 45.1% identity with Ang-1 and 59% identity with Angptl2. Angptl1 consists of an N-terminus with a coiled-coil domain，potential glycosylation sites and a C-terminus with a fibrinogen-like domain. It is a secreted protein but does not function as a growth factor in endothelial cells. Angptl1 plays a distinct role in the regulation of angiogenesis； inhibiting proliferation，migration，tube formation and endothelial cell adhesion. To exert this inhibitory activity，Angptl1 is speculated to interact with a receptor on endothelial cells. In a wide variety of tumor tissues，Angptl1 expression is down-regulated suggesting that a major function of this protein involves its antiangiogenic properties.
应用类型
Western blot: ~1:1000， IHC: ~1:50-1:100， FACS: ~1:10–1:50.
免疫原
This ANGPTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-44 amino acids from the N-terminal region of human ANGPTL1.
