ApoER2 （apolipoprotein E receptor 2），also designated LRP8，is a member of the LDL receptor gene family，which includes LDL receptor，LRP，megalin，VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats，epidermal growth factor （EGF）-like repeats，YWTD repeats and an O-linked sugar domain. ApoER2 is expressed in brain and placenta and has several splice variants. ApoER2 is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 （mammalian disabled protein），which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.
应用类型
Western blot: ~1:1000， IHC: ~1:50-1:100.
免疫原
This APOER2 （LRP8） antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 934-963 amino acids from the C-terminal region of human APOER2 （LRP8）.
