Angiotensin-converting enzyme （ACE） is a carboxy-terminal dipeptidyl exo-peptidase that converts Angiotensin I to the potent vasopressive hormone，Angiotensin II. There are two isoforms of ACE，the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung，liver，adrenal cortex，pancreas，kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells，specifically，late pachytene spermatocytes. Additionally，ACE inactivates bradykinin，a vasodepressor peptide，and is involved in fluid/electrolyte homeostasis. Although it bears significant sequence homology to ACE，ACE2 shows a more restricted pattern of expression. ACE is expressed ubiquitously throughout the vasculature while ACE2 is expressed only in cardiac，renal and testicular cells.
应用类型
Western blot: 1:1000
免疫原
This ACE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1274-1306 amino acids from the C-terminal region of human ACE.
