N6-methyladenosine (m6A)，or methylation of the N6 position of adenosine is a posttranscriptional modification of RNA. Due to a lack of analytical methods，N6-methyladenosine is poorly understood，but new evidence suggests that it is a very common base modification and important physiological regulator. N6-methyladenosine is markedly increased throughout brain development，and is enriched near stop codons，microRNA-binding sites and UTRs，which indicates a fundamental role in the regulation of gene expression. N6-methyladenosine is also highly conserved between human and mouse. The regulation of m6A modifications in mRNA has been linked to disease，where fat mass and obesity-associated (FTO) has been has been reported to be a obesity risk gene. FTO is a m6A demethylase and polymorphisms that result in increased FTO expression are associated with increased body mass and risk of obesity.
应用类型
Western blot, Dot Blot, Chromatin Immunoprecipitation (ChIP), RNA Binding Protein Immunoprecipitation (RIP).
免疫原
This antibody is generated from rabbits immunized with a BSA conjugated N6-Methyladenosine (BV-N13-14).
