DUSP3 belongs to the dual specificity protein phosphatase subfamily which inactivates their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSP3 negatively regulate members of the mitogen-activated protein kinase superfamily that are related to cellular proliferation and differentiation. DUSP3 is expressed in both breast and ovarian tissues and displays activity both for tyrosine-protein phosphate and serine-protein phosphate, but exhibits a strong preference toward phosphotyrosines, specifically dephosphorylates and inactivates ERK1 and ERK2.
序列
重组人DUSP3蛋白产品，又称Dual specificity protein phosphatase 3, VHR.其对应NCBI基因号为1845，对应Accession号为P51452.
来源宿主
提供的【DUSP3】重组人DUSP3产品的来源为大肠杆菌重组表达.
溶解建议
重组人DUSP3产品为液体即用型，其溶液组成为：1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2 mM DTT and 0.15 M NaCl.
