FKBP3 is part of a family of immunosuppressant receptors which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 accelerates the folding of proteins. FKBP3 is part of the immunophilin protein family, which participates in immunoregulation and fundamental cellular processes concerning protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a greater affinity for rapamycin than for FK506 and therefore is a significant protein for immunosuppression by rapamycin.
序列
重组人FKBP3蛋白产品，又称FK506 binding protein 3, FKBP25, PPIase FKBP3, Rotamase.其对应NCBI基因号为2287，对应Accession号为Q00688.
来源宿主
提供的【FKBP3】重组人FKBP3产品的来源为大肠杆菌重组表达.
溶解建议
重组人FKBP3产品为液体即用型，其溶液组成为：1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.
