Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a phosphoryl group from ATP to glucose to form glucose-6-phosphate and ADP. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV This enzyme is found in most cells, but there is tissue specificity for the particular type of hexokinase. Hexokinase 2 is found in the skeletal muscle and includes hydrophobic N-terminal sequence capable of targeting the hexokinase to mitochondria. It also constitutes the principal regulated isoform in many other cell types and is increased in many cancers. Although found in NIDDM patients, genetic variations of HK 2 do not contribute to the disease.
序列
重组人己糖激酶 2 蛋白产品，又称Hexokinase type II, Muscle form hexokinase, HK2.其对应NCBI基因号为3099，对应Accession号为P52789.
来源宿主
提供的【Hexokinase 2 】重组人己糖激酶 2 产品的来源为大肠杆菌重组表达.
溶解建议
重组人己糖激酶 2 产品为液体即用型，其溶液组成为：1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
