USP34 Core is a ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2，thereby acting as a regulator of Wnt signaling pathway. It acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2，leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin （CTNBB1）-mediated transcription. It recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. It is involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. Its catalytic core consists of residues 1892-2241.
应用类型
Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 ug/mL
