Synapsins are abundant brain proteins essential for regulating neurotransmitter release. All synapsins contain a short N-terminal domain that is highly conserved and phosphorylated by PKA or CaM kinase I. Phosphorylation of synapsin N-terminal domain at Ser9 inhibits its binding to phospholipids and diassociates synapsins from synaptic vesicles.
应用类型
Western blot analysis （0.5-4 ug/ml）. It detects the 60-80 kDa synapsins. Jurkat cell lysates and rat kidney tissue lysate can be used as positive controls. Blocking peptide （Cat.# 6008BP-50） is available separately.
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 12 of human synapsin
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的Synapsin蛋白发生免疫反应.
保存建议
提供的Synapsin抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该Synapsin抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
