Protein-tyrosine Phosphatase H1 (PTPH1) has recently been identified as a specific p38γ MAPK phosphatase which is mediated through PDZ interaction. Ras has been demonstrated to increase both p38 gamma and PTPH1 protein expression, and there is a coupling of increased p38 gamma and PTPH1 protein expression in primary colon cancer tissues. Phosphorylation of PTPH1 at Ser459 leads to PTPH1 stabilization, which plays an important role in Ras oncogenesis and stress response. Additionally, phosphorylation of PTPH1 Ser459 reveals a novel mechanism by which MAPK signals through PTPH1 to regulate cellular response. PTPH1 pS459 Antibody is ideal for researchers interested in cancer research.
应用类型
ELISA,Western Blot,
免疫原
Anti-Phospho-Ser459 PTPH1 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Ser459 of human PTPH1 conjugated to KLH.
来源宿主
Rabbit
反应性
H. sapiens (Human); Mus musculus (Mouse)
保存建议
Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilut
