Casp12 (Caspase 12 (Gene/Pseudogene)) has no protease activity. It may reduce cytokine release in response to bacterial lipopolysaccharide during infections. Caspase 12 reduces activation of NF-kappa-B in response to TNF. Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules. Anti-Caspase 12 Antibody is useful for researchers interested in Amyotrophic lateral sclerosis (ALS), ATP synthesis, and Apoptosis research.
应用类型
ELISA,IF Microscopy,Western Blot,
免疫原
Anti-Caspase 12 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal portion of mouse Caspase 12 conjugated to Keyhole Limpet Hemocyanin (KLH).
来源宿主
Rabbit
反应性
Mus musculus (Mouse); Rattus (Rat)
保存建议
Store vial at -20° C or below prior to opening. This vial contains a relatively low volume of reagent (25 µL). To minimize loss of volume dilute 1:10 by adding 225 µL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.
