Anti-Avian Influenza Hemmagglutinin 4 antibody detects the internal portion of Hemagglutinin protein. Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability. Anti-Avian Influenza Hemmagglutinin 4 antibodies are ideal for investigators involved in infectious diease research.
应用类型
ELISA,
免疫原
Avian Influenza Hemmagglutinin 4 Antibody was produced from whole goat serum prepared by repeated immunizations with a synthetic peptide corresponding to an internal region of the Hemagglutinin protein. Efforts were made to use relatively conserved regions of the viral sequence as the antigen.
来源宿主
Goat
反应性
Virus
保存建议
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
