BMPs (bone morphogenetic proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throμghout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF-beta superfamily are disulfide-linked dimmers composed of two 12-15 kDa polypeptide chains. As implied by their name，BMPs initiate，promote and regulate bone development，growth，remodeling and repair. Smad1 translocation to the nucleus is observed after the addition of BMP-4 (also designated BMP-2B)，sμggesting that BMP-4 may play a role in activation of the Smad pathway.
应用类型
Western blot, Immunohistochemistry
免疫原
Synthetic peptide surrounding amino acid 395 of human BMP-4
