DAP12 （KARAP） is a natural killer （NK） cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs （ITIM），DAP12 contains an immunoreceptor tyrosine-based activation motif （ITAM） in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Crosslinking of DAP 12-KIR complexes （membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain） results in cellular activation.
应用类型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 94 of mouse DAP-12
来源宿主
兔
反应性
经检测验证，可与小鼠、大鼠种属来源的DAP12蛋白发生免疫反应.
保存建议
提供的DAP12抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）缓冲液中.请将该DAP12抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
