C3a is an anaphylatoxin generated through activation of the complement C3. C3a is a potent chemoattractant for phagocytes，and it stimulates chemotaxis and other leukocyte functions. C3a binds to eosinophils，basophils，neutrophils，and differentiated U937 cells，that all express receptors for C3a on their cell surface. The C3a receptor has been cloned and shown to be a G protein-coupled receptor with seven putative transmembrane domains. This receptor is characterized for its large extracellular loop between the fourth and fifth transmembrane domains. The loop can be readily detected using the rabbit anti-C3a receptor antibody.
应用类型
The antibody recognizes C3aR expressed in leukocytes and in transfected cells using flow cytometry.
免疫原
E. coli expressed human C3aR （a.a. 161-332）
来源宿主
兔
反应性
经检测验证，可与人种属来源的C3aR蛋白发生免疫反应.
保存建议
提供的C3aR抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02%硫柳汞的PBS缓冲液中.请将该C3aR抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
