WD repeat domain 5 （WDR5） is a member of the WD repeat protein family，which is involved in a variety of cellular processes，including cell cycle progression，signal transduction，apoptosis，and gene regulation. WDR5，also known as BIG-3，is expressed in the developing growth plate，accelerates chondrocyte and osteoblast differentiation in vitro，and regulates osteoblast differentiation during embryonic bone development. WDR5 interacts with the pluripotency factor Oct4/POU5F1 and is required for the efficient formation of induced pluripotent stem （iPS） cells.
应用类型
Western Blot: 1 ug/ml， ICC: 5 ug/ml， ELISA. However， the optimal conditions should be determined individually.
免疫原
WDR5 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human WDR5.
