SDF-1B (stromal cell-derived factor-B)，also known as pre-B-cell growth-stimulating factor (PBSF)，is a 74-amino acid CXC chemokine originally cloned from a bone marrow stromal cell line. Targeted deletion of SDF-1 gene resulted in defects of B-cell lymphopoiesis and bone marrow myelopoiesis. SDF-1 has been shown to be chemotactic for lymphocytes. In addition，SDF-1 was recently reported to be a ligand for CXCR4 (LESTR/fusin)，a co-receptor for HIV-1 entry into T cells. SDF-1 binding to CXCR4 inhibits HIV-1 entry.
应用类型
Western blot, Immunoprecipitation, Immunohistochemistry
