The three mammalian isoforms of TGF-beta （TGF-beta1，TGF-beta2，TGF-beta3） signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation，growth，differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis，tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth，and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development.
应用类型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes~25 kDa TGF-B3 from samples of human， mouse， and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 254of human TGF-B3
来源宿主
兔
反应性
经检测验证，可与人、小鼠、大鼠种属来源的TGF-beta3蛋白发生免疫反应.
保存建议
提供的TGF-beta3抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS缓冲液中.请将该TGF-beta3抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.
