Polycomb group （PcG） proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I （PRC1） contains CBX4/Pc2，HPH1 and RING domain-containing proteins （RING1，RING2 and BMI1）. CBX4 （Chromobox protein homolog 4 or PC2），which functions as a transcriptional suppressor，is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
应用类型
Western Blot: 1 - 2 ug/ml， ELISA. However， the optimal conditions should be determined individually.
免疫原
CBX4 antibody was raised against a 17 amino acid peptide near the amino terminus of human CBX4.
