CASK （Calcium/calmodulin-dependent serine protein kinase），a conserved multi-domain scaffolding protein，belongs to a MAGUK （membrane-associated guanylate kinase homologs） subfamily and is involved in cell junction organization，tumor suppression and signaling. It is characterized by a novel domain structure that consists of a calcium/calmodulin-dependent protein kinase domain followed by PDZ，SH3 and guanylate kinase-like （GUK） domains. CASK is ubiquitously expressed and significantly greater in brain where it is thought to be involved in signaling at neuronal synapses. CASK interacts with CASKINs and defects in CASK are the cause of mental retardation X-linked CASK-related.
应用类型
Western Blot: 1 - 2 ug/ml， ELISA. However， the optimal conditions should be determined individually.
免疫原
CASK antibody was raised against a 16 amino acid peptide near the amino terminus of human CASK.
